A 29-year-old multigravida at 33 weeks and 2 days gestation presents for a routine prenatal visit in October. She has received an annual influenza vaccination and a Tdap booster earlier in this pregnancy. She asks whether she should receive the maternal respiratory syncytial virus (RSV) bivalent vaccine (Abrysvo) today. Which recommendation by the certified nurse-midwife is most appropriate based on current CDC immunization guidelines?
flowchart TD
GA{Gestational Age Check} -->|< 32 Weeks| Wait[Defer administration until 32w0d]
GA -->|32w0d to 36w6d| Season{Seasonal Window: Sep-Jan?}
GA -->|> 36w6d| Infant[Recommend infant nirsevimab after birth]
Season -->|Yes| Administer[Administer 1 dose maternal RSV vaccine]
Season -->|No| Infant
Answer and explanation
Correct answer: C
Abrysvo is given between 32 0/7 and 36 6/7 weeks gestation from September through January in the continental US to prevent infant RSV. Routine infant nirsevimab is the alternative.
Q2Question 2
IntermediateMultiple answers
Antepartum · Orders immunizations in pregnancy.
A 24-year-old primigravida at 28 weeks gestation presents for routine prenatal care in November. Review of her medical chart shows that she has received no vaccines during the current pregnancy. Her prenatal rubella titer is non-immune. Which TWO vaccines should the certified nurse-midwife recommend administering during today's visit? (Select TWO)
Answer and explanation
Correct answers: D, E
Tdap is recommended during each pregnancy between 27 and 36 weeks. Inactivated influenza vaccine is safe and indicated in any trimester during flu season. Live vaccines like MMR and LAIV are contraindicated.
Q3Question 3
Beginner
Antepartum · Orders immunizations in pregnancy.
True or False: Administration of the live attenuated influenza vaccine (LAIV) via nasal spray is safe and clinically acceptable in pregnant individuals during any trimester.
Answer and explanation
Correct answer: A
LAIV is a live attenuated virus and is strictly contraindicated during pregnancy due to theoretical risks to the fetus. Inactivated or recombinant influenza vaccines should be given instead.
Q4Question 4
Beginner
Antepartum · Orders Rh immunoglobulin when indicated during pregnancy.
A primigravida at 28 weeks gestation has blood type A-negative with a negative indirect Coombs antibody screen. The pregnancy has been uncomplicated with no history of bleeding or invasive procedures. What is the standard management plan for this patient?
Answer and explanation
Correct answer: A
Unsensitized Rh(D)-negative pregnant individuals should receive a standard 300 mcg dose of Rh immune globulin at 28 weeks gestation to prevent alloimmunization against fetal Rh-positive red cells.
Q5Question 5
Advanced
Antepartum · Orders Rh immunoglobulin when indicated during pregnancy.
A 31-year-old G2P1 at 19 weeks gestation presents to the obstetric triage unit following a moderate motor vehicle collision where she was the belted driver. She reports lower abdominal soreness from the lap belt. Physical examination reveals mild localized uterine tenderness without palpable contractions. Speculum examination demonstrates a closed cervix without vaginal bleeding or leaking amniotic fluid. Maternal vital signs are stable, and fetal heart tones are 144 bpm with moderate variability.
Her blood type is O-negative, and her initial prenatal antibody screen was negative. Which clinical intervention regarding Rh isoimmunization prevention should the certified nurse-midwife initiate next?
Answer and explanation
Correct answer: C
Blunt abdominal trauma risks fetomaternal hemorrhage. Unsensitized Rh-negative individuals must receive 300 mcg RhIG within 72 hours, with Kleihauer-Betke testing to assess for larger hemorrhage requiring extra doses.
Q6Question 6
Intermediate
Antepartum · Orders Rh immunoglobulin when indicated during pregnancy.
For an unsensitized Rh(D)-negative individual experiencing a spontaneous first-trimester abortion at 7 weeks gestation, the standard recommended minimum dose of Rh(D) immune globulin to prevent maternal alloimmunization is _____.
Answer and explanation
Correct answer: B
A 50 mcg microdose of Rh(D) immune globulin protects against up to 2.5 mL of Rh-positive red blood cells, which is adequate for fetomaternal hemorrhage occurring before 12 weeks of gestation.
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